AbstractJapanese pine sawyer beetle, pine shoot beetle, and Formosan subterranean termite were selected to investigate the inhibitory abilities of solid wood and wood-based composites (MDF and WPCs) made with Eucalyptus urograndis and Melaleuca leucadendra. The chemical components in the extractives of the two types of wood were also analyzed by GC-MS. The results indicated that the inhibitory ability can generally be listed in descending order as WPCs, MDF, and solid wood when made by the same wood filler. However, samples in each group made using Melaleuca leucadendra exhibited a higher inhibitory level than samples made using Eucalyptus urograndis. 2,3-dihydro-2,2-dimethyl-3,7-benzofurandiol, which was identified in the extractives of both woods (14.169% in Eucalyptus urograndis and 12.686% in Melaleuca leucadendra), was a significant factor for inhibition due to its high toxicity to insects. The chemical components with greatest potential for inhibition were stigmast-4-en-3-one (8.656%) in Eucalyptus urograndis andboth 3-demethyl-colchicine (2.642%) and squalene (1.649%) in Melaleuca leucadendra. Additionally, perlite-based MDF showed the best inhibitory ability, possibly because the alimentary of the insects are prone to injury by perlite. PVC-based WPCs had a greater inhibitory level than HDPE-based WPCs due to the presence of the Cl element in PVC, as well as the addition of calcium zinc stabilizer and inorganic filler.