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Teng, J., Ma, H., Wang, F., Wang, L., and Li, X. (2016). "A facile and eco-effective catalytic system for synthesis of 5-hydroxymethylfurfural from glucose," BioRes. 11(1), 2152-2165.


A facile and eco-friendly system for synthesis of 5-hydroxymethylfurfural (HMF) from glucose has been investigated with the catalyst dihydric phosphate (H2PO4—) in a methyl isobutyl ketone (MIBK)/H2O biphasic system. The results showed that the catalyst dosage, reaction temperature, and reaction time had noticeable effects on glucose conversion and the HMF yield; more than 50% yield of HMF was achieved at the optimum conditions. In addition, this catalytic system was broadly substrate-tolerant; a satisfactory HMF yield was obtained from higher substrate concentrations and complex substrates. Furthermore, this efficient catalyst was recycled up to nine consecutive times without the loss of catalytic activity.
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