NC State
Hao, W., Tang, X., Zeng, X., Sun, Y., Liu, S., and Lin, L. (2015). "Catalytic conversion of glucose to levulinate ester derivative in ethylene glycol," BioRes. 10(3), 4191-4203.


A comprehensive, kinetic experiment on the conversion of glucose to 2-hydroxyethyl levulinate ethylene ketal (HLEK), in a cascade of reactions in ethylene glycol, catalyzed by low-concentration sulfuric acid, was conducted. The ethylene glycol/sulfuric acid system was found to be tolerant of a high glucose concentration, and no solid humins were created. At a high initial glucose concentration (30 wt %), an HLEK yield of 27.6% was achieved at a moderate temperature (433 K) after a 330-min reaction with dilute sulfuric acid (0.15 mol/L). In ethylene glycol, more than half of the initial glucose was converted into glucosides within 5 min, and a dynamic equilibrium between these species was achieved; thus, it is reasonable to assume that the ratio of glucosides to glucose was constant (1.35:1) during the entire reaction process. The production of HLEK from glucose via glucosides as a function of the process variables was well-represented by a simplified first-order kinetic model, and the rate expressions were applied to determine the optimum conditions for batch processing.
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