Factors affecting screw driving torques in plywood were investigated in this work. The factors were number of layers (7 and 9), pilot hole diameter (3.0 and 3.5 mm), pilot hole depth (60 and 80% of the thickness of specimen), and thickness of the metal plate (7.5 and 10 mm). Screw driving torques were studied in oriented strandboard, medium-density fiberboard, particleboard, and some wood-plastic composites. There is no such information about screw driving torques in plywood (PW). Therefore, this study focused on the plywood made of aspen (Populus tremula L.). The mean seating torque (SET) values ranged from 0.31 to 0.69 N∙m, whereas mean stripping torque (STT) values ranged from 0.50 to 4.7 N∙m. The ratios of STT/SET were between 2 and 5 in PW with seven layers, whereas the ratios were between 4 and 7 in PW with nine layers. The results indicated that the four main effects of SET and STT were statistically significant with p-values of ˂ 0.0001.