AbstractAn investigation was conducted on the adsorption of oxymatrine (OMT) on a spherical cellulose adsorbent embedded with wattle bark tannin. The results showed that the adsorption of the OMT on the adsorbent was solution pH dependent and the adsorption process followed the Freundlich adsorption isotherm. The adsorption kinetics of the OMT on the adsorbent could be well described by the pseudo-second-order rate model. And, the adsorption capacity calculated by the pseudo-second-order rate model was close to the experimental data. Desorption and regeneration experiments showed that the OMT adsorbed on the adsorbent could be easily recovered by 50% methanol solution.