Transforming an innovation into a start-up company can be highly rewarding to the technologist. This editorial considers technology selection for a start-up company. A simple system for screening initial of technologies is given. This editorial is based on years of experience working in translating technologies into start-up companies by the author. These companies have approached their start-up strategies in a variety of different ways. It is important for the technologist to enter into a start-up venture with an understanding of how their technology is positioned both technically and from a business perspective.