A high-speed milling experiment on wood-plastic composites was performed using cemented carbide tools, and the resulting wear pattern was studied. The influence of the cutting parameters, the cutting speed, feed speed, and axial cutting depth on the tool wear was studied via response surface methodology, and the influence of the interaction of the cutting parameters on tool wear was analyzed. Three-dimensional surface graphs and contour plots of the tool wear results were established. According to the experimental results, a mathematical model of the tool wear based on the second-order response surface methodology was established, and the model was utilized to verify its feasibility. The results show that the nose width (NW) increases with the increase of the cutting speed and axial cutting depth and decreases with the increase of feed speed. Among the factors affecting tool wear, the cutting speed had the greatest influence, followed by the feed rate, with the axial cutting depth affecting tool wear the least. According to the results of the interaction between the tool wear and the cutting parameters, a low feed speed and small axial cutting depth can be selected to ensure long tool life; for low-speed cutting, a high feed speed and large axial cutting depth can be adopted to ensure tool life while improving machining efficiency.