Transport coefﬁcients and correlations recently used to describe surfactant contribution to particle and water transport in a laboratory ﬂotation column were used to simulate the impact of surfactant contamination on the ﬂotation selectivity of industrial two-stage deinking lines. Simulation results showed that surfactants are slightly removed in the ﬁrst ﬂotation stage and are concentrated in the second one, where they induce a drop in ink ﬂotation and in ﬁbre entrainment. Subsequently, ﬂotation units in the second stage displayed lower ink removal than in the ﬁrst stage. In the presence of a constant water reject ﬂow, the increase in surfactant contamination in the pulp stock gave a general decrease in the removal of suspended solids. Surfactant removal increased from 5 to 50%, however, this increase was not sufﬁcient to prevent surfactant accumulation in the deinking line. Simulation results were compared with data collected in an industrial deinking line running in similar conditions and pulp composition, ink and surfactant removal obtained with low surfactant contamination were in line with experimental data.