The mean arithmetic deviation of the roughness profile (Ra) was investigated for the edge surface after edge milling of medium-density fiberboard, medium-density fiberboard with single-sided lamination, and spruce edge-glued panel. Tungsten carbide blades with three different compositions and treatment (HW1, HW2, and HW1 + CrTiN coating) were used. During edge milling, the feed rate (4, 8, and 11 m/min) and cutting speed (20, 30, 40, and 60 m/s) were changed. The lowest roughness values were found in spruce timber, and the highest values were found in untreated MDF. The highest edge surface roughness was measured after using the HW2 tool. Slightly lower values were found using HW1 CrTiN, and the lowest values were found using HW1. Increasing the cutting speed led to a very slight increase in roughness. Increasing the feed rate had the same effect, but its effect was more significant. The article provides an understanding of the interaction of the most frequently occurring factors relative to the quality of the work surface of the large-area materials.